pH- and Thermosensitive Supramolecular Assembling System: Rapidly Responsive Properties of β-Cyclodextrin-Conjugated Poly(ε-lysine)
- 1 May 2003
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (21), 6350-6351
- https://doi.org/10.1021/ja034149x
Abstract
Beta-Cyclodextrin-conjugated poly(epsilon-lysine) (beta-CDPL) was synthesized as a novel polymeric host for constructing a smart supramolecular assembling system. Systematic studies on the inclusion complexation between the polymeric host with an alpha- or beta-CD cavity and a model guest molecule provided evidence that dual cooperative interactions, specific host-guest interaction and intermolecular ionic interaction, played a dominant role in leading to a fast aggregation phenomenon. In addition, a rapid phase transition induced by the supramolecular assembly was observed reversibly in response to a small change in pH or temperature.Keywords
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