THE DIODRAST CLEARANCE AND RENAL BLOOD FLOW IN NORMAL PREGNANT AND NON-PREGNANT WOMEN

Abstract

Simultaneous detns. were made of the plasma clearances of diodrast, urea, and endogenous quot;creatinine" in 17 normal women, 8 of whom were pregnant and near term. The effective renal blood flow was calculated by dividing the plasma fraction into the plasma clearance of diodrast. The renal blood flow avgs. 856 ml. per 1.73 sq. m. per min., and ranges from 694 to 1233 ml. The standard deviation is 126 [plus or minus] 14.8 ml., and the standard error of the mean is 30.6 ml. Many data from comparative physiology are cross-calculated; all indicate that human renal blood flows close to the levels found by the diodrast clearance method. The urea extraction ratio averages 8.6%. The plasma clearance of endogenous "creatinine," measured by the Jaffe reaction, does not seem to bear any fixed relation to the glomerular filtration.