Catalytic Enantioselective Reaction of Diketene with Aldehydes Catalyzed by Chiral Schiff Base-Titanium Alkoxide Complexes

Abstract

The catalytic enantioselective reaction of diketene with aldehydes was achieved by the use of a catalytic amount (20 mol%) of chiral Schiff base to afford the corresponding 5-hydroxy-3-oxoesters with high enantioselectivity.