PAPAVERINE, an opium derivative frequentlyused to combat vascular spasm, was first advocated for the treatment of angina pectoris in 1913 by Pal1; no data were presented, however. Three years later, Macht2 reported temporary relief of angina pectoris in 3 patients following injection of 40 mg. of papaverine. In 1923, Pal3 described prompt but transient relief of angina pectoris after the injection of 20 to 30 mg. of papaverine intravenously in an eighteen-year-old patient with aortic stenosis and insufficiency; subcutaneous injections of larger doses were not so effective. In 1921, Boehm4 reported marked success in treating patients with angina pectoris . . .