Usefulness of Electron Beam Tomography in Adolescents and Young Adults With Heterozygous Familial Hypercholesterolemia
- 8 December 1998
- journal article
- other
- Published by Wolters Kluwer Health in Circulation
- Vol. 98 (23), 2580-2583
- https://doi.org/10.1161/01.cir.98.23.2580
Abstract
Background —Because of the success of secondary prevention of coronary events by intense risk factor modification, a more precise measure of atherosclerosis in youth would have great clinical value both in the design of clinical trials for the demonstration of the usefulness of coronary disease prevention early in life and in guiding therapy. Identification of calcium in coronary arteries by electron beam tomography has been associated with severity of atherosclerosis in adults. Methods and Results —Twenty-nine youths 11 to 23 years old with familial hypercholesterolemia (average LDL cholesterol, 5.95 mmol/L) underwent electron beam tomography as well as comprehensive risk factor assessment with measurement of total cholesterol, triglycerides, HDL cholesterol, lipoprotein (a), apolipoprotein E phenotype, blood pressure, body mass index, and history of tobacco use. Significant coronary calcium was identified in 7 of 29 subjects. Increased body mass index was significantly associated with the presence of coronary calcium (25.3 versus 20.6 kg/m 2 , P Conclusions —Coronary calcium, uncommonly identified before the fourth decade, was found in a significant percentage of adolescents and young adults with familial hypercholesterolemia. Overweight may increase the likelihood of coronary calcium being present in individuals already at high risk.Keywords
This publication has 12 references indexed in Scilit:
- Association between Multiple Cardiovascular Risk Factors and Atherosclerosis in Children and Young AdultsNew England Journal of Medicine, 1998
- Importance of intra-abdominal visceral fat accumulation to coronary atherosclerosis in heterozygous familial hypercholesterolaemiaInternational Journal of Obesity, 1997
- Relation of cholesterol-year score to severity of calcific atherosclerosis and tissue deposition in homozygous familial hypercholesterolemiaThe American Journal of Cardiology, 1996
- Coronary risk factors measured in childhood and young adult life are associated with coronary artery calcification in young adults: The muscatine studyJournal of the American College of Cardiology, 1996
- Effects of secular trends in obesity on coronary risk factors in children: The Bogalusa Heart StudyThe Journal of Pediatrics, 1995
- Noninvasive tracking of coronary atherosclerosis by electron beam computed tomography: Rationale and design of the Felodipine Atherosclerosis Prevention Study (FAPS)The American Journal of Cardiology, 1995
- Differences in prevalence and extent of coronary artery calcium detected by ultrafast computed tomography in asymptomatic men and womenThe American Journal of Cardiology, 1993
- Noninvasive definition of anatomic coronary artery disease by ultrafast computed tomographic scanning: A quantitative pathologic comparison studyJournal of the American College of Cardiology, 1992
- Quantification of coronary artery calcium using ultrafast computed tomographyJournal of the American College of Cardiology, 1990
- Relation of Serum Lipoprotein Levels and Systolic Blood Pressure to Early AtherosclerosisNew England Journal of Medicine, 1986