(S)-(–)-1-Amino-2-(siloxymethyl)pyrrolidines: novel and efficient reagents for chromatographic resolution of α-substituted aldehydes

Abstract

A new aldehyde resolution technique based on the chromatographic separation (preparative h.p.l.c.) of their epimeric (S)-1-amino-2-(siloxymethyl)pyrrolidine (SASP)-hydrazones is described.