Telomere Reduction of Specific Chromosome Translocation in Acute Myelocytic Leukemia
- 1 February 1994
- journal article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 85 (2), 127-130
- https://doi.org/10.1111/j.1349-7006.1994.tb02071.x
Abstract
The length of telomere restriction fragments (TRF) was studied by Southern blotting in 42 patients with acute myelocytic leukemia (AML) including 15 patients with 8;21 translocation, 8 with 15;17 translocation and 19 with a normal karyotype. The TRF length of leukemic cells with a normal karyotype and with 8;21 or 15;17 translocation showed significant reduction compared to that of lymphocytes from normal individuals (P<0.05). In addition, there was a statistically significant difference in TRF length between leukemic cells with a normal karyotype and 8;21 translocation (P<0.05). Therefore, the significant difference of telomere reduction in 8;21 translocation may be an important factor in the leukemogenic process.Keywords
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