Epicardial Coronary Artery Compliance in the Dog

Abstract

The dynamic compliance of 21 coronary arteries from 17 dogs was determined in situ. Intramyocardial portions were occluded with a mixture of 200µ glass beads and liquid silicone. To simulate in vivo pressure-volume conditions, 0.1 ml of saline was injected in 150 to 240 msec at a rate of 30 pulses/min. Silicone casts of the vessels, made at 100 mm Hg distending pressure, were used as a reference volume. The results indicate that the dynamic compliance decreases as the initial distending pressure rises. The change in volume for a 50 mm Hg pressure increment (initial distending pressure of 100 mm Hg) was 3.7 ± 0.6% (mean ± SE). In four dogs, phasic flow in the left circumflex coronary artery was measured. The volume of systolic flow per beat during the control state was of the same order of magnitude as the compliance of the vessels; however, during reactive hyperemia, systolic coronary flow markedly exceeded the dynamic compliance of the coronary vessels. In six dogs the static compliance of a segment of coronary artery was obtained radiographically. A 30.1 ± 1.4% change in volume occurred when the intravascular pressure was increased from 70 to 120 mm Hg.