RELATIONSHIP BETWEEN THE PARATHYROID AND THE GASTRIC GLANDS IN THE DOG

Abstract

The effects of the parathyroid hormone (Parathormone) and thyroparathyroidectomy on gastric secretion in dogs with Pavlov pouch, Heidenhain pouch, and esophagotomy with a gastric fistula have been studied. Gastric secretion was provoked by test meals of bread, milk or meat, subcutaneous histamine, intravenous insulin, and sham feeding. An increase of 2 mg. % in the serum Ca decreased the vol. and acidity of the gastric secretion of the innervated gastric pouch, while that of the denervated pouch was increased. In some cases the gastric secretory response did not return to normal levels for some time after the discontinuation of the inj. of Parathormone. Thyroparathyroidectomy increased the vol. and acidity of gastric secretion in all the animals. Both the conc. and total output of pepsin were decreased. Histological examination of the gastric glands showed a diminution in the number and distribution of pepsinogen granules. The effects of thyro-parathyroidectomy were diminished by the inj. of Ca lactate or Parathormone. Na lactate and thyroxine did not abolish the gastric hypersecretion following thyropara-thyroidectomy.