CD4+ and CD19+ splenocytes undergo apoptosis during an experimental murine infection with Taenia crassiceps
- 26 February 2003
- journal article
- research article
- Published by Springer Nature in Zeitschrift Fur Parasitenkunde-Parasitology Research
- Vol. 90 (2), 157-163
- https://doi.org/10.1007/s00436-003-0829-2
Abstract
The Taenia crassiceps cysticercus is a cestode that naturally and experimentally infects rodents in which it reproduces by budding. In the laboratory, a persistent cellular immunosuppression with a concomitant increasing load of parasites has been observed in experimentally infected BALB/cAnN mice. In this study, enhanced apoptosis was found in spleen cells from 30-day infected mice with a typical "ladder-patterned" DNA fragmentation and an increase in phosphatidylserine expression. A characteristic poly-(ADP-ribose) polymerase cleavage indicates that this cell death is caspase-mediated. Apoptosis was detected in the CD4+ and CD19+ splenocytes of infected mice after in vitro stimulation with cysticercal antigens. Considering previous results on the crucial role that CD4+ T cells play in controlling the extent of infection, apoptosis in this T-lymphocyte subpopulation induced by T. crassiceps cysticerci could be responsible for the immunosuppression that underlies parasite success.Keywords
This publication has 48 references indexed in Scilit:
- CD4 + TCRαβ T cells are critically involved in the control of experimental murine cysticercosis in C57BL/6J miceZeitschrift Fur Parasitenkunde-Parasitology Research, 2001
- Tripeptidyl Peptidase II Promotes Maturation of Caspase-1 inShigella flexneri-Induced Macrophage ApoptosisInfection and Immunity, 2000
- Parasite‐secreted products regulate the host response to larval Taenia crassicepsParasite Immunology, 2000
- Cellular Changes and Apoptosis in the Spleens and Peripheral Blood of Mice Infected with Blood-StagePlasmodium chabaudi chabaudiASInfection and Immunity, 2000
- Detection of DNA Fragmentation and Endonucleases in ApoptosisMethods, 1999
- Recognition and phagocytosis of cells undergoing apoptosisBritish Medical Bulletin, 1997
- Activation–mediated CD4+ T cell unresponsiveness during acute Toxoplasma gondii infection in miceInternational Immunology, 1996
- Apoptosis and the maintenance of homoeostasis in the immune systemCurrent Opinion in Immunology, 1996
- Apoptosis in the Pathogenesis and Treatment of DiseaseScience, 1995
- STUDIES ON THE BIOLOGY OF TAENIA CRASSICEPS (ZEDER, 1800) RUDOLPHI, 1810 (CESTODA)Canadian Journal of Zoology, 1962