Degree and Duration of Reversal by Naloxone of Effects of Morphine in Conscious Subjects
- 15 June 1974
- Vol. 2 (5919), 589-591
- https://doi.org/10.1136/bmj.2.5919.589
Abstract
The effects of intravenous naloxone on several of the actions of intravenous morphine (mean dose 30 mg/70 kg) were studied in six volunteer subjects. Naloxone produced a well defined reversal of the respiratory depression, analgesia, and miotic and subjective effects of the morphine. The agonist action of morphine outlasted the antagonist action of a single dose of naloxone. The effect of repeated doses of naloxone was also short-lived, but continuous infusions were effective in maintaining reversal.Keywords
This publication has 11 references indexed in Scilit:
- TREATMENT OF DRUG OVERDOSAGE WITH NALOXONE, A SPECIFIC NARCOTIC ANTAGONISTThe Lancet, 1973
- Treatment of Propoxyphene Overdosage with NaloxoneChest, 1973
- The Antagonism of Morphine Anesthesia by NaloxoneAnesthesia & Analgesia, 1971
- Metabolites of Naloxone in Human UrineJournal of Pharmaceutical Sciences, 1971
- Isolation of two different glucuronide metabolites of naloxone from the urine of rabbit and chicken.1969
- The respiratory, circulatory, and narcotic antagonistic effects of nalorphine, levallorphan, and naloxone in anaesthetized subjectsCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 1969
- Naloxone in heroin dependenceClinical Pharmacology & Therapeutics, 1968
- Naloxone Reversal of Pentazocine-Induced Respiratory DepressionJAMA, 1968
- Antagonism of the subjective, behavioral, pupillary, and respiratory depressant effects of cyclazocine by naloxoneClinical Pharmacology & Therapeutics, 1968
- N-ALLYLNOROXYMORPHONE - A NEW POTENT NARCOTIC ANTAGONIST1963