Histocompatibility-2 system in wild mice

Abstract

Thirteen new B10.W congenic lines carrying wild-derivedH-2 haplotypes on the genetic background of the C57BL/10Sn (=B10) strain, were analysed serologically for antigens encoded by theH-2K andH-2D loci. The analyses resulted in the description of 12 new private or low-frequency public H-2 antigens (designated H-2.127 through H-2.130, and H-2.133 through H-2.142) and six newH-2 haplotypes (designatedH-2 ^w21 throughH-2 ^w27 ). Six inbred, private or low-frequency public H-2 antigens were also found in the B10.W lines: H-2.17 in B10.CHA2, H-2.19 in B10.GAA37, H-2.21 in B10.DRB62 and B10.WOA105, H-2.25 in B10.STA62, H-2.31 in B10. KPA44 and B10.KEA5, and H-2.32 in B10.BUA16 and B10.BUA19. Virtually all these antigens occur in combinations with other class I antigens not represented among the available inbred strains, and thus constitute naturalH-2 recombinants. Lines B10.LIB55, B10.STA10, and B10.STA12 appear to share the sameK andD alleles; serologically indistinguishable are also lines B10. BUA16 and B10.BUA19, and B10.WOA105, B10.SNA57, and B10.DRB62.