Bromoacetylalprenololmenthane binding to β-receptors modulates the rate of hormone-induced internalization but not desensitization in S49 cells
- 20 April 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 214 (2), 323-326
- https://doi.org/10.1016/0014-5793(87)80079-0
Abstract
Bromoacetylalprenololmenthane was found to inhibit hormone-induced β-adrenergic receptor internalization in a dose-dependent fashion in S49 lymphoma cells, besides its known ability to bind to β-receptors irreversibly. This new found property of BAAM+ was taken advantage of in studying whether receptor internalization is a necessary step in the desensitization of adenylate cyclase. BAAM-treated cells showed functional desensitization even when receptor internalization had been blocked substantially by 50–65% This finding suggests that receptor internalization is not directly involved in desensitization.Keywords
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