Early Transient Accumulation of Methotrexate in the Cerebrospinal Fluid of Rabbits after Treatment with Methotrexate and Roentgen Rays
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Acta Radiologica: Oncology
- Vol. 23 (1), 69-73
- https://doi.org/10.3109/02841868409135989
Abstract
Concomitant application of intrathecal methotrexate (MTX) and cranial irradiation was described as being able to cause brain abnormalities in patients with leukemia. Rabbits were treated once weekly for 6 wk with intraventricular MTX and irradiation. Cerebrospinal fluid (CSF) sampled at various time points after each treatment contained for the samples obtained 4 h after treatment increasing amounts of MTX. This indicated a retardation in MTX clearance from the CSF. Such a retardation might contribute to the generation of brain abnormalities, although no data have as yet been obtained to prove this suggestion.This publication has 5 references indexed in Scilit:
- A peculiar brain scan pattern in necrotizing leukoencephalopathy after treatment for CNS-leukaemiaClinical Neurology and Neurosurgery, 1979
- The effect of photon irradiation on blood-brain barrier permeability to methotrexate in miceCancer, 1977
- Disseminated necrotizing leukoencephalopathy: A complication of treated central nervous system leukemia and lymphomaCancer, 1975
- Necrotizing Encephalopath Following Intraventricular Instillatio of MethotrexateArchives of Neurology, 1973
- POTASSIUM EFFECTS ON ION TRANSPORT IN BRAIN SLICESJournal of Neurochemistry, 1968