A 13C NMR Study on Trichodermin. Spectral Assignments, Spin-Lattice Relaxation, and Biosynthetic Incorporation of Sodium [1-13C]-Acetate.

Abstract

Unambiguous assignments of the 13C FT [Fourier transform] NMR spectra of trichodermin [an antifungal antibiotic produced by Trichoderma viride] and some related compounds were obtained. Biosynthetic incorporation of sodium [1-13C]-acetate into trichodermin was studied by means of 13C NMR spectroscopy. Spin-lattice relaxation times gave information on the molecular reorientational correlation times in chloroform solutions of trichodermin and on the internal motion of the methyl groups.