TRANSFER OF SENSITISED LYT 2+ CELLS TRIGGERS ACUTE REJECTION OF PANCREATIC ISLET ALLOGRAFTS

Abstract

The cellular requirements for rejection of cultured islet allografts, a tissue expressing only class I alloantigens, have been studied. The results obtained show that sensitised Thy 1+, Lyt 2+ lymphocytes and not Lyt 2- lymphocytes trigger acute graft rejection.