Well-Defined, Organic Nanoenvironments in Water: The Hydrophobic Effect Drives a Capsular Assembly
- 24 August 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (37), 11408-11409
- https://doi.org/10.1021/ja0475611
Abstract
The synthesis of a water-soluble, deep-cavity cavitand is reported. A blend of molecular curvature and amphiphilicity, this molecule has a hydrophobic concave surface and a hydrophilic convex surface. As a result, in aqueous solution and in the presence of a guest molecule, the host self-assembles to form a capsular assembly with an interior cavity large enough to entrap steroidal guests.Keywords
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