The transmural passage of blood cells into myeloid sinusoids and the entry of platelets into the sinusoidal circulation; a scanning electron microscopic investigation
- 1 February 1976
- journal article
- research article
- Published by Wiley in Journal of Anatomy
- Vol. 145 (2), 183-205
- https://doi.org/10.1002/aja.1001450204
Abstract
Scanning electron microscopic observations of rat bone marrow reveal that the sinusoidal wall is continuous and has no permanent patent apertures allowing free communication between the extravascular and intravascular myeloid compartments. Blood cells migrate into the sinusoids by perforating the endothelial cell body. Platelets are derived from long intrasinusoidal “proplatelet” processes which originate from the cell body of extravascularly located megakaryocytes. Proplatelet processes frequently occur in clusters, with the probability that all processes in a cluster arise from a single megakaryocyte. The release of platelets into the circulation may be initiated by local constriction along these processes, at which places either individual platelets or larger segments of proplatelet cytoplasm are pinched off. The larger segments may subsequently undergo further fragmentation into individual platelets.Keywords
This publication has 26 references indexed in Scilit:
- Endocytosis, transfer tubules, and lysosomal activity in myeloid sinusoidal endotheliumJournal of Ultrastructure Research, 1975
- Structural Identification of Thrombosthenin in Rat MegakaryocytesScandinavian Journal of Haematology, 1972
- An electron microscope study of the rat megacaryocyteJournal of Ultrastructure Research, 1969
- An electron microscope study of the megacaryocyte of the rat bone marrowJournal of Ultrastructure Research, 1968
- Fine structure of the bone marrow of the chicken and pigeonJournal of Morphology, 1967
- Thrombosthenin—A contractile protein from thrombocytes. Its extraction from human blood platelets and some of its propertiesBiochimica et Biophysica Acta, 1961
- THE EFFECT OF REDUCED OXYGEN TENSION ON PLATELET FORMATIONIN VITROJournal of Clinical Pathology, 1958
- THE FINE STRUCTURE OF THE MEGAKARYOCYTE IN THE MOUSE SPLEENCells Tissues Organs, 1957
- The histogenesis of the blood plateletsJournal of Morphology, 1910
- Die Entstehung der BlutplättchenVirchows Archiv, 1906