Copper Complexes of Thiosemicarbazone−Pyridylhydrazine (THYNIC) Hybrid Ligands: A New Versatile Potential Bifunctional Chelator for Copper Radiopharmaceuticals
- 16 December 2005
- journal article
- Published by American Chemical Society (ACS) in Inorganic Chemistry
- Vol. 45 (2), 496-498
- https://doi.org/10.1021/ic0514492
Abstract
Two new thiosemicarbazone−pyridylhydrazine (THYNIC) hybrid ligands have been synthesized. Copper(II) and copper(I) complexes of the ligands have been prepared and characterized by X-ray crystallography. Cyclic voltammetry measurements show that the copper(II) complexes undergo quasi-reversible reductions at biologically accessible potentials. One of the ligands, bearing a pendant carboxylate arm, has been conjugated to N-α-(tert-butoxycarbonyl)-l-lysine.Keywords
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