Allergic contact dermatitis to topical corticosteroids: clobetasol propionate and clobetasone butyrate

Abstract
Two case reports are given of patients with positive patch test reactions to clobetasol propionate. One of the patients also reacted to clobetasone butyrate and 30 other steroids, that were chemically very closely related to these two 21-chloro-9-.alpha.-fluoro-corticosteroids, were patch test negative. The literature on contact dermatitis reactions to corticosteroids is reviewed.