GONADOTROPHIN RESPONSES TO GnRH IN PRECOCIOUS PUBERTY TREATED WITH GnRH ANALOGUE

Abstract
The gonadotropin-releasing hormone (GnRH] analog Buserelin was given by intranasal spray to 13 children with precocious puberty. The LH [luteinizing hormone] responses to GnRH reverted to prepubertal levels in the boys on 200-400 .mu.g daily of the analog while doses of 400-1200 .mu.g daily were needed to suppress the girls. The significance of this apparent sex difference is uncertain.