PROBABLE CURE OF METASTATIC TESTICULAR-TUMORS TREATED WITH SEQUENTIAL THERAPY

Abstract

The possibility of inducing long-term unmaintained complete remissions in testicular cancer using sequential multimodality therapy was studied. A combination of vinblastine and bleomycin for 3 courses followed by cis-dichlorodiammineplatinum(II), actinomycin D and vincristine was used until a surgically proven complete remission was achieved. One to three additional consolidation courses were given following surgery; then all therapy was stopped. Of 15 patients completing therapy, 11 have achieved complete remission, with 7 patients remaining free of diease without maintenance therapy for 15-36 mo. (average, > 27 mo.). Patients with disseminated nonseminomatous testicular cancer apparently should be treated for cure with intensive primary therapy. Prolonged disease-free status can be achieved without maintenance therapy; the value of maintenance therapy needs further study.