Induction of murine B cell proliferation by insolubilized anti-immunoglobulins.
- 1 September 1980
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 125 (3), 1240-1242
- https://doi.org/10.4049/jimmunol.125.3.1240
Abstract
This study demonstrates that intact antibodies specific for mu, delta, or light chains when coupled to Sepharose are effective in delivering proliferative signals to B cells. Furthermore, using Sepharose-coupled anti-delta antibodies, we have shown that hybridoma anti-delta (that is not active as soluble protein) is as effective as rabbit anti-delta in activating murine B cells. However, antibodies directed against two other surface molecules, I-A and H-2K, were not mitogenic. Thus, sIgM and sIgD are comparable in their ability to transmit a proliferative signal to the B cell and sIg seems to play a unique role in this regard.This publication has 1 reference indexed in Scilit: