5-HT1A receptor function in depression: effect of chronic amitriptyline treatment
- 1 June 1990
- journal article
- research article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 80 (2), 157-161
- https://doi.org/10.1007/bf01257081
Abstract
Hypothermic responses to 5-HT1A receptor activation by the selective ligand ipsapirone (IPS) were attenuated in depressed patients as compared to controls. Chronic treatment with amitriptyline (AMI) further impaired 5-HT1Amediated hypothermia. The results indicate a subsensitive (presynaptic) 5-HT1A receptor and/or a defective post-receptor signalling pathway in depression and are consistent with the hypothesis that 5-HT1A receptors are down-regulted during AMI treatment.Keywords
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