A comparison of three guinea‐pig sensitization procedures for the detection of 19 reported human contact sensitizers
- 1 October 1981
- journal article
- research article
- Published by Wiley in Contact Dermatitis
- Vol. 7 (5), 248-258
- https://doi.org/10.1111/j.1600-0536.1981.tb04060.x
Abstract
A maximization test (after Magnusson and Kligman), a single injection adjuvant test (SIAT) and a modified Draize test procedure for assessing contact sensitization potential in guinea-pigs were compared for their ability to detect 19 known human contact sensitizers. The modified Draize procedure is a good screening test particularly for strong sensitizers. The maximization procedure is a very stringent test of sensitization potential, able to detect some marginal sensitizers. The sensitivity of the SIAT procedure is sufficiently similar to that of the maximization test to act as an alternative for routine testing, particularly in view of its practical advantages over the maximization procedure.Keywords
This publication has 9 references indexed in Scilit:
- Predictive evaluation in animals of the contact allergenic potential of medically important substances I. Comparison of different methods of inducing and measuring cutaneous sensitizationContact Dermatitis, 1978
- The sensitization potential of some perfume ingredients tested using a modified Draize procedureToxicology, 1978
- Sensitization and Testing of Guinea Pigs with Nickel SulfateDermatology, 1976
- Attempts to induce sensitization in guinea pigs with nickel complexesActa Dermato-Venereologica, 1975
- The frequency of contact sensitivity in North America 1972–74 North American Contact Dermatitis GroupContact Dermatitis, 1975
- Identification of Certain Sultones as the Sensitizers in an Alkyl Ethoxy SulfateFette, Seifen, Anstrichmittel, 1975
- The Identification of Contact Allergens by Human AssayJournal of Investigative Dermatology, 1966
- Delayed Contact Hypersensitivity In the Guinea PigArchives of Dermatology, 1965