Lack of Correlation between Human Herpesvirus-6 Infection and the Course of Human Immunodeficiency Virus Infection
- 28 February 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 161 (3), 567-570
- https://doi.org/10.1093/infdis/161.3.567
Abstract
Human herpesvirus-6 (HHV-6) and human immunodeficiency virus (HIV) are both tropic for CD4+ lymphocytes. 10 determine whether HHV-6 infection affects the susceptibility to or the course of HIV infection, HHV-6 titers were measured by an anticomplement immunofluorescence assay in serum of three groups of homosexual or bisexual men: (1) those with AIDS (n = 78), (2) those with HIV-associated lymphadenopathy (LAS; n = 81), and (3) those who were HIV-seronegative (n = 55). Early and late serum samples were available for 45 men with LAS (median interval 49 months). Men with early LAS did not differ from HIV-seronegative men in either the percentage that were HHV-6-seropositive or in the distribution of titers. There was a significantly lower percentage of seropositives in AIDS patients than in the other two groups (P < .01). LAS patients who progressed to AIDS did not differ in percentage seropositivity or distribution of titers from nonprogressors. HHV-6 titers tended to decrease over time. HHV-6 titers late in LAS were similar to those in AIDS patients. These findings suggest that it is unlikely that previous exposure to HHV-6 either predisposes to or affects the course of HIV infection.This publication has 8 references indexed in Scilit:
- Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virusJournal of Virology, 1989
- Transactivation of human immunodeficiency virus promoter by human herpesvirus 6Journal of Virology, 1989
- CLINICAL AND SEROLOGICAL FEATURES OF HUMAN HERPESVIRUS-6 INFECTION IN THREE ADULTSThe Lancet, 1988
- IDENTIFICATION OF HUMAN HERPESVIRUS 6-SPECIFIC DNA-SEQUENCES IN 2 PATIENTS WITH NON-HODGKINS LYMPHOMA1988
- IDENTIFICATION OF HUMAN HERPESVIRUS-6 AS A CAUSAL AGENT FOR EXANTHEM SUBITUMThe Lancet, 1988
- In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6).The Journal of Experimental Medicine, 1988
- DETECTION OF HUMAN B-LYMPHOTROPIC VIRUS (HUMAN HERPESVIRUS-6) SEQUENCES IN B-CELL LYMPHOMA TISSUES OF 3 PATIENTS1988
- Isolation of a New Virus, HBLV, in Patients with Lymphoproliferative DisordersScience, 1986