Modification of BSP metabolism by bile stasis and liver injury

Abstract

Excretion of BSP into bile by the liver of the rat was prevented or reduced by temporary bile stasis, carbon tetrachloride intoxication, or whole-body x-ray. BSP was injected, bile was collected for a standard period of time and the BSP excreted into bile was analyzed for distribution among its metabolic products. An increase was found in the compound representing the apparent terminus of the metabolic sequence, indicating that metabolism of BSP had continued during the delay in excretion. The results suggest that an immediate consequence of bile stasis is an arrest of the net secretion of BSP, whether fluid continues to be secreted or not. The possible relationship of the effects of the delay in excretion of BSP to the apparent concentration of BSP in plasma is pointed out.