Increase in Circulating Red Cell Volume of Normal and Hypophysectomized Rats after Treatment with ACTH.

Abstract
Red cell volumes were detd. in normal and hypophysectomized rats and normal and hypophysectomized rats treated with ACTH using the P32 tagged cell method. Admn. of ACTH prevented the decrease in the total circulating red cell volume which is normally found in hypophysectomized rats, and admn. of ACTH for 116 days to normal rats elevated the total circulating red cell volume to approx. 1.3 times that of the normal untreated controls.