ANDROGEN RELEASE AND SYNTHESIS IN VITRO BY HUMAN ADULT ADRENAL GLANDS*
Open Access
- 1 January 1963
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 42 (1), 64-78
- https://doi.org/10.1172/jci104697
Abstract
Dehydroepiandrosterone, androstenedione, and 11[beta]-hydroxyandrostenedione were released by adrenal slices into the media after 3 hours incubation. The addition of ACTH increased 11[beta]-hydroxyandrostenedione release in all normal and pathological tissues but not usually the other androgens. Adrenal androgens are converted predominantly in "normal", hyperplastic, and adenomatous slices from 17a-hydroxypregnenolone-dehydroepiandrosterone-androstenedione 11[beta]-hydroxyandrostenedione rather than from progesterone-* androstenedione-* 11B-hydroxyandrostenedione.Keywords
This publication has 45 references indexed in Scilit:
- A RAPID, SENSITIVE ASSAY PROCEDURE FOR ADRENAL STEROID-3β-OL-DEHYDROGENASE ACTIVITY12Endocrinology, 1961
- CORTICOSTEROID RELEASE AND SYNTHESIS IN VITRO BY ADRENAL SLICES FROM PATIENTS WITH CUSHING'S SYNDROME*JCI Insight, 1961
- SOME STUDIES ON THE BIOSYNTHESIS OF ALDOSTERONE AND OTHER ADRENAL STEROIDSActa Endocrinologica, 1960
- Steroid Formation by Adrenal Tissue from Hypertensives1JCI Insight, 1958
- BIOSYNTHESIS OF DELTA-4-ANDROSTENEDIONE AND 17-ALPHA-HYDROXYPROGESTERONE FROM PROGESTERONE BY SURVIVING HUMAN FETAL ADRENALS1958
- METABOLISM OF PROGESTERONE BY ADRENAL TISSUE FROM PATIENTS WITH CUSHING'S SYNDROME AND MAMMARY CARCINOMA*†Journal of Clinical Endocrinology & Metabolism, 1958
- The excretion of allotetrahydrocortisol in human urineBiochemical Journal, 1957
- THE CONVERSION OF ACETATE TO C19 STEROIDS BY HUMAN ADRENAL GLAND SLICESJournal of Biological Chemistry, 1957
- METABOLISM OF 11-BETA-HYDROXY-DELTA(-4)-ANDROSTENE-3,17-DIONE IN MAN1957
- THE ISOLATION OF Δ4-ANDROSTENE-ll β-OL-3,17- DIONE FROM HUMAN ADRENAL INCUBATES*Journal of Clinical Endocrinology & Metabolism, 1955