Cyanide intoxication in the rat: physiological and neuropathological aspects.
Open Access
- 1 February 1976
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 39 (2), 129-140
- https://doi.org/10.1136/jnnp.39.2.129
Abstract
Sodium cyanide was given to rats by intravenous infusion at a rate that would avert apnoea (the first sign of overdosage) in the majority. There was full physiological monitoring in a group under anaesthesia and more limited monitoring in an unanaesthetized group. White matter was damaged in six animals and grey matter additionally in only one. It was concluded that cyanide can damage neurones only through the medium of secondary effects on circulation and respiration.Keywords
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