Differentiation of Certain Platelet Factors Related to Blood Coagulation

Abstract

Study of the platelets from the viewpoint of the blood coagulation mechanisms seems likely to be helpful for increasing our knowledge of thrombosis, and bleeding tendencies in thrombasthenias and thrombopathias. A logical approach to their study is the differentiation of their properties and where possible to ascribe those properties to individual components. Platelet factors 1, 3 and 4 are considered from that viewpoint. The first accelerates the formation of thrombin in a manner analogous to serum Ac-globulin. Factor 3 is required for the development of threone activity, and factor 4 has antiheparin properties.