The yjeQ Gene Is Required for Virulence of Staphylococcus aureus
- 1 August 2006
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 74 (8), 4918-4921
- https://doi.org/10.1128/iai.00258-06
Abstract
Gene products required for in vivo growth and survival of Staphylococcus aureus and other pathogens represent new targets for antimicrobial chemotherapy. In this study we created a Staphylococcus aureus yjeQ deletion strain and tested its virulence using a mouse kidney abscess infection model. The yjeQ deletion strain was compromised for growth in vitro and severely attenuated for virulence. We concluded that yjeQ is an attractive and novel new drug target.Keywords
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