Pinealectomy Abolishes 6-Hydroxymelatonin Excretion by Male Rats
- 1 August 1982
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 111 (2), 425-426
- https://doi.org/10.1210/endo-111-2-425
Abstract
The principal urinary metabolite of the pineal gland hormone melatonin was measured in pinealectomized and sham-operated male rats and shown to be a valid index of pineal gland activity. Pinealectomy decreased its excretion by 97–99%. Extrapineal synthesis of melatonin does not contribute significantly to circulating melatonin, as determined by this integrative measure of its major conjugated metabolite.Keywords
This publication has 4 references indexed in Scilit:
- Light Exposure Reduces and Pinealectomy Virtually Stops Urinary Excretion of 6-Hydroxymelatonin by Rhesus MonkeysEndocrinology, 1982
- Quantitative analysis of 6-hydroxymelatonin in human urine by gas chromatography-negative chemical ionization mass spectrometryAnalytical Biochemistry, 1981
- A Specific Radioimmunoassay for Melatonin in Biological Tissue and Fluids and its Validation by Gas Chromatography-Mass SpectrometryEndocrinology, 1977
- The Fate of Melatonin in AnimalsJournal of Biological Chemistry, 1961