Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.
- 1 January 1983
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 80 (1), 273-277
- https://doi.org/10.1073/pnas.80.1.273
Abstract
The murine Ia antigens, encoded by the I region of the major histocompatibility complex, are cell-surface glycoproteins (consisting of .alpha. and .beta. polypeptides) thought to be involved in the control of immune responsiveness. Mice of haplotypes b, s, q and f fail to express one of the Ia antigen complexes, the E complex, on the cell surface. How such a defect (or defects) might be generated was studied at the molecular level. By using I-region E.alpha. and A.alpha. gene probes for analyses of RNA and DNA structure, it was concluded that at least 3 mechanisms can operate. Mice of haplotypes b and s bear a deletion in the E.alpha. gene; f haplotype mice synthesize predominantly an E.alpha. mRNA of aberrant size; and mice of the q haplotype have a defect in RNA processing or a problem with mRNA stability, or both.This publication has 19 references indexed in Scilit:
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