Dopamine: Release from the Brain in vivo by Amantadine
- 22 October 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 174 (4007), 408-410
- https://doi.org/10.1126/science.174.4007.408
Abstract
After dopamine stores in the caudate nucleus of cats were labeled with [3H]dopamine, the ventricular system was perfused with artificial cerebrospinal fluid. The addition of amantadine to the perfusing fluid caused a doserelated increase in the concentrations of [3H]dopamine appearing in the perfusion effluent. Subthreshold concentrations of amantadine also enhanced the efflux of [3H]dopamine induced by electrical stimulation of the caudate nucleus.Keywords
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