Standardized skin burn injuries were induced in 253 NMRI mice. The burned surface corresponded to 15% of the total surface of a 25 g mouse. All animals received i.p. injection of an isotonic saline solution in a dose of 20% of body weight/day for 5 days. The material was divided into 3 groups, i.e., group A (controls) which received no further treatment, groups B and C which also received triglycylvasopressin (a vasopressin with prolonged effect) 100 and 200 .mu.g/kg body weight, respectively, s.c. twice a day. The highest survival rate was registered in group B (61%), while the controls had a survival of 36%.