PRE-ZYGOTIC SELECTION OF MALE GAMETES IN LABORATORY MICE

Abstract

The frequency of aneuploid male gametes was related to the number of early embryos with numeral chromosomal aberrations in progeny of male mice, heterozygous for the Robertsonian translocations T1 (15.6) AlD, and T1 (17.8) IEM. In mice heterozygous for translocation T1 (15.6) AlD, the number of spermatocytes II with NF [diploid number] = 21 was very low and corresponded to the number of trisomic embryos at stages of major organogenesis. In mice heterozygous for T1 (17.8) IEM translocation, the number of aneuploid gametes was 26.2%, but none of their progeny, on the 8th-12th days of gestation, was trisomic. The involvement of chromosomes 8 and 17 in the control of postmeiotic stages of spermatogenesis in mice was suggested.