Cerebrospinal fluid enolase in stroke.

Abstract

This study relates the level of .alpha. and .gamma. enolase in CSF sampled within 4 days of a stroke to the volume of the cerebral infarct measured on the CT image and to the clinical outcome of the patient. Patients (28) were studied, 2 with transient ischemia attacks and 26 with completed stroke due to infarction. The CSF enolase was raised in the 2 patients with transient ischemic attacks and 23 completed stroke. There was a positive correlation between the volume of the infarct and the level of CSF .alpha. and .gamma. enolase. A high CSF enolase was always associated with a poor prognosis.