Palladium- and Copper-Catalyzed Solution Phase Synthesis of a Diverse Library of Isoquinolines
- 3 September 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Combinatorial Chemistry
- Vol. 11 (6), 1061-1065
- https://doi.org/10.1021/cc9000949
Abstract
The solution-phase synthesis of a 111 member isoquinoline library is described. The isoquinoline scaffold has been accessed through the palladium- and copper-catalyzed cyclization of iminoalkynes and the palladium-catalyzed iminoannulation of internal alkynes, followed by diversification of hydroxyl functionality where it is present.Keywords
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