PHARMACOLOGICAL ANALYSIS OF SEROTONIN GROWTH-STIMULATING ACTIVITY IN CELL-CULTURES

Abstract

Serotonin (10-7 M) stimulated cell proliferation in the primary cultures of mouse and human embryonic fibroblasts mouse L-cells (neoplastic fibroblast) and in monkey kidney cells (MA). The stimulatory effect is completely prevented by cultured cell pretreatment with the serotonin antagonists tipindol, morphine and cyproheptadine, which do not affect cell proliferation. The stimulatory action of serotonin on these cells is realized via specific serotonin receptors.