Assisted Hatching—A Meta-Analysis of Randomized Controlled Trials
- 1 January 2003
- journal article
- clinical trial
- Published by Springer Nature in Journal of Assisted Reproduction and Genetics
- Vol. 20 (8), 332-342
- https://doi.org/10.1023/a:1024865725713
Abstract
Purpose: To conduct a meta-analysis of randomized controlled trials (RCTs) on assisted hatching. Methods: One hundred sixty-five studies were retrieved from the literature, but only 13 of them fitted our selection criteria. The meta-analysis was conducted using the RevMan software with the Peto-modified Mantel–Haenszel method. Results: Assisted hatching increases the pregnancy [OR (±95% CI) = 2.51 (1.91–3.29)], implantation [OR (±95% CI) = 2.38 (1.87–3.03)], and ongoing pregnancy rates [OR (±95% CI) = 2.65 (1.85–3.79)] significantly in poor prognosis patients undergoing IVF or ICSI. For patients with repeated IVF failures, the OR (±95% CI) were 2.84 (1.99–4.06) for pregnancy, 2.53 (1.85–3.47) for implantation, and 3.51 (2.12–5.82) for ongoing pregnancy rates, in favor of assisted hatching. Conclusions: Assisted hatching increases the pregnancy, implantation, and ongoing pregnancy rates significantly in patients with a poor prognosis undergoing IVF or ICSI, particularly those with repeated failures.Keywords
This publication has 20 references indexed in Scilit:
- Fertilization and early embryology: Zona opening of human embryos using a non-contact UV laser for assisted hatching in patients with poor prognosis of pregnancyHuman Reproduction, 1996
- Infertility: Enhancement of outcome from intracytoplasmic sperm injection: does co-culture or assisted hatching improve implantation rates?Human Reproduction, 1996
- Zona thinning with the use of laser: a new approach to assisted hatching in humansHuman Reproduction, 1996
- Does assisted hatching improve implantation rates after in vitro fertilization or intracytoplasmic sperm injection in all patients? A prospective randomized studyJournal of Assisted Reproduction and Genetics, 1996
- Clinical approaches to increasing uterine receptivity during human implantationHuman Reproduction, 1995
- Assisted hatching by partial zona dissection of human pre-embryos in patients with recurrent implantation failure after in vitro fertilizationFertility and Sterility, 1995
- Fertilization and early embrology: Monozygotic twinning in the human is associated with the zona pellucida architectureHuman Reproduction, 1994
- Chemical removal of the outside of the zona pellucida of day 3 human embryos has no impact on implantation rateJournal of Assisted Reproduction and Genetics, 1993
- Impairment of the hatching process following IVF in the human and improvement of implantation by assisting hatching using micromanipulationHuman Reproduction, 1990
- Comparison of zona cutting and zona drilling as techniques for assisted fertilization in the mouseReproduction, 1988