ALTERATIONS IN RENAL AND AORTIC PROSTAGLANDIN-E AND PROSTAGLANDIN-F FORMATION CORRELATE WITH BLOOD-PRESSURE INCREASE IN SALT LOADED RATS AFTER DIETARY LINOLEATE DEFICIENCY

Abstract

For 4 wk, male Wistar rats received a linoleic acid (LA)-rich (13.3 cal % LA) or deficient (0.5 cal % LA) diet as well as 1.5% NaCl as drinking fluid. Compared with the LA-rich diet, the LA-deficient diet caused an increase in blood pressure of .apprx. 10 mm Hg. Indomethacin treatment (2 .times. 1 mg/kg per day s.c.) increased the blood pressure in the LA-rich but not LA-deficient fed rats. The flow rate of isolated perfused kidneys was reduced after 4 wk LA-deficient diet, as were aortic and renal PG[prostaglandin]E formation; whereas PGF formation was only slightly diminished. PGE2 degradation in the kidney was not influenced by the LA content of the diet. Apparently, the prohypertensive effect of LA-deficient diet in salt-loaded rats is mediated via a reduction of endogenous PGE formation and a shift towards PGF.