Citrate Cleavage Enzyme in Livers of Obese and Nonobese Mice
- 22 May 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 144 (3621), 1027-1028
- https://doi.org/10.1126/science.144.3621.1027
Abstract
The specific activity of the citrate cleavage enzyme is 3.3 times greater in livers of obese mice than in livers of their nonobese litter mates. The difference persists during starvation. The specific activity of the acetate activating enzyme is approximately the same in the livers of both types of animals. It is proposed that a high activity of citrate cleavage enzyme is one of the factors responsible for obesity.Keywords
This publication has 21 references indexed in Scilit:
- Citrate and the conversion of carbohydrate into fat. A comparison of citrate and acetate incorporation into fatty acidsBiochemical Journal, 1964
- The incorporation of citrate carbon into fatty acidsBiochimica et Biophysica Acta, 1963
- The Supply of Precursors for the Synthesis of Fatty AcidsJournal of Biological Chemistry, 1962
- Utilization of citric acid carbon for the biosynthesis of long-chain fatty acidsBiochimica et Biophysica Acta, 1962
- Incorporation of radioactive citrate into fatty acidsBiochimica et Biophysica Acta, 1962
- Aspects of the Glucose and Amino Acid Metabolism in the Liver and the Diaphragm of Normal and Obese‐Hyperglycemic MiceActa Physiologica Scandinavica, 1961
- Feedback Control by Endproduct InhibitionPublished by Cold Spring Harbor Laboratory ,1961
- The choice of the suspension medium for rat-liver-cell nucleiBiochemical Journal, 1956
- AN ENZYMATIC REACTION BETWEEN CITRATE, ADENOSINE TRIPHOSPHATE AND COENZYME A1Journal of the American Chemical Society, 1953
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951