Tetracycline Binding by Skeletal Tissue

Abstract

Skeletal maturation reduced the uptake of large doses of tetracycline by the skeleton. The diminished responsiveness of bone did not demonstrably alter the relative importance of the teeth as sites of binding of tetra-cyclines. The maximal degree of binding of tetracycline by the skeleton was approximately 5% of the administered intraperitoneal dose in young rats and was about 1% in more mature animals.