Structure of the Human Telomere in K+Solution: An Intramolecular (3 + 1) G-Quadruplex Scaffold
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- 7 July 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (30), 9963-9970
- https://doi.org/10.1021/ja062791w
Abstract
We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K+ solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na+ solution and in a K+-containing crystal, involves the following: one anti·syn·syn·syn and two syn·anti·anti·anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.Keywords
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