Unexpected Detection of Melanoma Brain Metastasis by PET With Iodine-124 βCIT
- 1 October 2009
- journal article
- case report
- Published by Wolters Kluwer Health in Clinical Nuclear Medicine
- Vol. 34 (10), 698-699
- https://doi.org/10.1097/rlu.0b013e3181b53654
Abstract
To study the potential impact of iodine-124-beta-carbomethoxy-3beta(4-iodophenyl)tropane (I-124 betaCIT) in Parkinson disease, a I-124 betaCIT-PET scan was performed in 30-year-old man with suspected early Parkinson disease. The scan showed normal striatum uptake together with a focal spot in the left parietal cortex. The subsequent magnetic resonance imaging of the brain revealed a corresponding nodular lesion, presumably representing a metastasis. After clinical and diagnostic evaluation, a malignant metastatic melanoma was discovered. betaCIT is a cocaine derivative with a high affinity for dopamine and serotonin transporters mainly used to image the density of the dopamine reuptake transporter. In fact the role of I-123 betaCIT is typically represented by Parkinsonian syndromes of uncertain classification. The iodine-124 betaCIT uptake is a marker of dopamine transporters density, and the presence of focal uptake corresponding to a lesion on magnetic resonance images suggests a specific binding in this case of melanoma brain metastasis.Keywords
This publication has 6 references indexed in Scilit:
- Male Primary Breast Cancer Found on FDG-PET/CTClinical Nuclear Medicine, 2008
- Serendipitous Detection of Testicular Seminoma on F-18 FDG Positron TomographyClinical Nuclear Medicine, 2007
- Incidental Diagnosis of Endometrial Carcinoma in a Patient With Breast Cancer by FDG PET/CTClinical Nuclear Medicine, 2007
- Incidental PET/CT Detection of Thyroid and Breast Cancer During Recurrence of Colorectal CarcinomaClinical Nuclear Medicine, 2007
- Bilateral adrenal metastases from malignant melanoma: concordant findings on 18F-FDG and 18F-FDOPA PETEuropean Journal of Nuclear Medicine and Molecular Imaging, 2006
- Incidental Detection of Colon Cancer by FDG Positron Emission Tomography in Patients Examined for Pulmonary NodulesClinical Nuclear Medicine, 2002