An immunocytochemical study of the inflammatory cell infiltrate and epithelial expression of HLA‐DR in odontogenic cysts
- 1 March 1987
- journal article
- research article
- Published by Wiley in Journal of Oral Pathology & Medicine
- Vol. 16 (3), 112-117
- https://doi.org/10.1111/j.1600-0714.1987.tb01476.x
Abstract
The presence and distribution of lymphocytes, Langerhans cells, HLA-DR' infiltrating cells and the expression of HLA-DR by lining epithelium was investigated in the walls of odonlogenic cysts using an indirect immunoperoxidase method on acetone-fixed cryostat sections. The 23 cysts studied consisted of 14 dental (radicular) cysts, 5 keratocysts, 2 dentigerous cysts, 1 surgical ciliated cyst and 1 incisive canal cyst. The cell populations detected in the walls of all cysts were similar and consisted of HLA-DR+ macrophage-type cells and a mixture of T and B lymphocytes. Analysis of the T cell subsets revealed that in all cases the CD4+, Th/i subset predominated over the CD8+, Ts/c subset. 18/22 cyst linings contained cells expressing a Langerhans cell phenotype (CD1+). Cytoplasmic epithelial expression of HLA-DR was detected in 7/22 specimens. Neither the presence of HLA-DR+ epithelial cells nor LC were restricted to a given type of cyst. These findings indicate the occurrence of similar cellular processes irrespective of the proposed developmental or inflammatory aetiology of these lesions.This publication has 29 references indexed in Scilit:
- In situ characterisation of the oral mucosal inflammatory cell response of rats induced by 4-nitroquinoline-N-oxideCarcinogenesis: Integrative Cancer Research, 1986
- Expression of Class I and Class II major histocompatibility complex antigens on epithelial cells in recurrent aphthous stomatitisJournal of Oral Pathology & Medicine, 1986
- Gingival keratinocytes express HLA-DR antigens in chronic gingivitisJournal of Oral Pathology & Medicine, 1985
- Glycosaminoglycans in fluid aspirates from odontogenic cystsJournal of Oral Pathology & Medicine, 1984
- Oral lichen planus: an immunoperoxidase study using monoclonal antibodies to lymphocyte subsetsBritish Journal of Dermatology, 1984
- Langerhans' cells and T cells in human skin tumours: an immunohistological studyHistopathology, 1984
- Langerhans Cells: Role in Contact Hypersensitivity and Relationship to Lymphoid Dendritic Cells and to MacrophagesImmunological Reviews, 1980
- The Functional Role of Langerhans CellsJournal of Investigative Dermatology, 1980