The Tissue Proton T1 and T2 Response to Gadolinium DTPA Injection in Rabbits A Potential Renal Contrast Agent for NMR Imaging

Abstract

Three different doses of gadolinium (Gd) DTPA were administered i.v. to rabbits. Cardiovascular responses and changes in blood T1 and T2 were serially followed for 15 min when the animals were sacrificed for in vitro measures of tissue T1 and T2. Gd-DTPA was distributed and excreted like water soluble iodinated contrast agents with large changes in blood, urine and kidney proton relaxation. An imaging experiment confirmed the efficacy as an NMR contrast agent for renal excretion. At effective doses, no adverse effects were observed and the agent appeared to be much safer than X-ray contrast agents, but with a similar potential for clinical utility.