Severe experimental hyperthyroidism in the ruminant. II. Physiological effects

Abstract

SUMMARY: 1. The physiological effects of severe hyperthyroidism on five sheep are described.2. Increases in pulse rate of more than 100% were observed. The increase in pulse rate was proportional to dosage with the exception of one sheep which had lesions on the chordae tendinae of the left ventricle.3. The heart, even though beating at this elevated rate, reacted normally to severe exercise, but there was a tendency for the sheep to carry out its normal functions at a slower rate so such large increases in pulse rate did not occur as the result of voluntary activity.4. Considerable cardiac arrhythmia was noticed in all hyperthyroid sheep.5. The relative increases in pulse rate of the cow and the sheep given iodinated casein of the same potency suggest that as between species dosage of iodinated casein is proportional to ‘metabolic body size’—the between species unit of basal metabolism—rather than to body weight itself. On this basis the stimulation of the sheep was between 1 and 4 times the dosage accepted as normal for the cow.6. Body temperatures increased in the most severely affected animals. Respiratory rates quadrupled in some cases.