Methylprednisolone as an Antiemetic

Abstract

To the Editor: A recent casual observation that premedication with intravenous methylprednisolone prevented nausea and vomiting in a patient who was receiving chemotherapy and had previously had severe nausea and vomiting led us to conduct a trial of methylprednisolone given before chemotherapy in patients with lymphomas.In the past five months I have treated 55 patients with intravenous methylprednisolone: 18 of them had myeloma, 21 Hodgkin's disease, eight various types of lymphocytic lymphomas, seven diffuse histiocytic lymphoma, and one angioimmunoblastic lymphadenopathy. The 18 patients with myeloma were receiving the M2 regimen (cyclophosphamide, melphalan, vincristine, carmustine, and prednisone). One of the . . .